EMCDDA: Směrnice pro testování uživatelů drog na infekční choroby

OXYCONTIN: Analgetikum – anodynum

• učinná látka oxykodon, tableta s prodlouženým uvolňováním, min. 8hod. intervaly
• SÚKL: https://prehledy.sukl.cz/prehledy/v1/dokumenty/66925

OxyContin abusers often chew the tablets or crush the tablets and snort the powder. Because oxycodone is water soluble, crushed tablets can be dissolved in water and the solution injected. The latter two methods lead to the rapid release and absorption of oxycodone.

Oxycodone vs. OxyContin: OxyContin is a brand-name version of the extended-release form of oxycodone....

Oxykodon je v per os podobě s rychlým i řízeným uvolňováním. U řízeného uvolňování je počáteční dávka obvykle 20 mg po 12 hodinách. Nástup účinku je kolem 2 hodin
K dispozici je také kombinovaný přípravek v podobě oxykodon + naloxon, který je výhodný pro pacienty s úpornou zácpou...

"Opiátová krize v USA" – příběh Purdue Pharma

Firma, kterou vlastní rodina Sacklerových, je kvůli OxyContinu předmětem tisíců žalob. OxyContin byl podle nich v USA jedním ze spouštěčů tzv. opioidové krize, která stála od roku 1999 životy až půl milionu lidí.

•   Léky s opiáty zabily až půl milionu lidí. Firma platí miliardy a bankrotuje

•   Seznamte se, Sacklerovi. Léky miliardářů spustily epidemii, která zabíjí více lidí než zbraně

•   Sága rodu Sacklerů aneb Vítězství hamižnosti - monografie Příběhy spojené s objevy nových léčiv (Stanislav Rádl, VŠCHT, 2023) - Blíží se pokrok v boji proti zneužívání opiátů? (2024)

•   Seriál Netflixu: Painkiller, 2023

•   Revealed: How the Sackler family’s opioid empire continues to make hundreds of millions of dollars in profits around the world

Praxe

•  Austrálie 2024
 

Wastewater-based evaluation of the efficacy of oxycodone regulations in Australia

Prescription changes lead to drop in oxycodone use
use of the opioid oxycodone in Australia almost halved after changes to packaging and prescribing practices in 2019; by reducing package size, adding warnings to packaging and educating health professionals

•  Warnings over opioid use spook EU countries into action

•  USA: Evidence on Strategies for Addressing the Opioid Epidemic (2017) - 100+ zdrojů !

• The Evolving Consequences of OxyContin Reformulation on Drug Overdoses (2020)
there was a transition from consumers seeking legally produced synthetic opioids (i.e. oxycodone) to seeking illegally manufactured heroin. This was attributed, in part, to the reformulation of oxycodone, which made it difficult to crush or dissolve

• Measuring prescription opioid misuse and its consequences (2021)

 

Decrease in past‐month prescription opioid misuse and increase in heroin use among people entering treatment for treatment misuse

Oxycodone and Hydrocodone: Detection in Urine, Oral Fluid, and Blood (SAMSHA 2014)

"Léčba"

Oxycodone: A Current Perspective on Its Pharmacology, Abuse, and Pharmacotherapeutic Developments (2023, +correction): kap. Vaccines to Treat Opioid Use Disorders

Pharmacological mechanisms underlying the efficacy of antibodies generated by a vaccine to treat oxycodone use disorder (2021) - oxycodone vaccine currently undergoing clinical testing

A Multifaceted Analysis of Oxycodone Addiction

An Exploratory Study of OxyContin Use Among Individuals with Substance Use Disorders

Changing patterns in opioid addiction - Characterizing users of oxycodone and other opioids (2009)

Evropa a syntetické opiáty

• Is Europe facing an opioid crisis like the United States? An analysis of opioid use and related adverse effects in 19 European countries between 2010 and 2018

• EUDA: Currently, synthetic opioids play a relatively small role in the drug market in Europe overall, but they are a significant problem in some countries, and there are signals that they could have the potential to play a larger role in Europe’s drug problems in the future. In 2023, new synthetic opioids were detected by the EU Early Warning System on new psychoactive substances in at least 16 EU Member States, Norway and Türkiye (see New psychoactive substances – the current situation in Europe).

• The looming threat of synthetic opioids in Europe?

• Monitoring Opioids in Europe: The Need for Shared Definitions and Measuring Drivers of Opioid Use and Related Harm (2022)
-increasing trends in prescription opioid use have been described for several European countries, including Germany [35], France [36], the United Kingdom [37], Spain [38], Poland [39], and the Netherlands [40]
 (https://www.politico.eu/article/spains-cautionary-tale-on-painkillers/)

 • Synthetic opioids in Poland—A cause for concern or a media distraction? (2024)
- although Polish physicians are increasingly more likely to prescribe synthetic opioids like OxyContin or Fentanyl, their problematic use remains low.
- synthetic opioids in Europe are often not sold under their brand names, but are used as adulterants to enhance the perceived quality of heroin


„NABÍDKA“
https://www.mimibazar.cz/inzerat/104882808/originalni-leky-na-prodej-oxycontin
https://www.motoinzerce.cz/dily/ruzne-dily/1151175-neurol-1mg-oxykodon-80mg-ketamin-rivotril-2mg-na-prodej.html
https://globalmedsonlineinc.com/product/pain-killers/oxycodone/